The Philippine Tuberculosis Society was founded on July 29, 1910 by a small group of Filipinos and Americans. They were led by the Society’s first president, Eleanor Franklin Egan, and Sixto delos Angeles. The Society operated two small clinics in Manila until they were able to expand activities and open the Santol Sanatorium in 1918.
In 1934, President Manuel Quezon signed Republic Act No. 4130, or the Sweepstakes Law, to address the public health threat of TB. With the founding of the Quezon Institute, the organization opened more clinics and TB pavilions across the country until the start of war.
During World War II, the Quezon Institute was occupied by Japanese forces and used as a military hospital, resulting in the loss of several important records, equipment, and supplies. The United States and the National TB Association helped the Society recover after the war.
The Philippine Tuberculosis Society was incorporated as the Philippine Tuberculosis Society, Inc. (PTSI) in 1960. In the decades that followed, PTSI partnered with several public and private organizations, including the Department of Health (DOH) and the World Health Organization (WHO), to expand its treatment, research, and training capabilities. It established its National Research and Training Center and Central Laboratory, now one of the leading TB laboratories in the country.
From 1987 onwards, the Quezon Institute adopted and pioneered the implementation of the Directly Observed Treatment Short Course (DOTS), a six-month treatment course for TB patients.